Nonapeptide-1, aussi called Expired melanostatin ™ 5 is a propriety That Was Originally Developed for ict antimicrobial peptide activities. Animal research Revealed HAS, HOWEVER, That nonapeptide-1 can inhibit the synthesis of melanin, qui Makes It Treating of interest for some skin conditions. Animal models suggest That can Reduce nonapeptide-1 synthesis of melanin and help Decrease skin pigmentation to a substantial businesses degree.
Sequence (Three-Letter Code): Met-Pro-D-Phe-Arg-Trp-D-Phe-Lys-Pro-Val
Molecular formula : C61H87N15O9S
Molecular weight : 1206.52 g / mol
Nonapeptide-1 is of primary interest for research icts Ability to Reduce hyperpigmentation by inhibiting the actions of tyrosinase in melanin-producing cells. The Ability to Regulate melanin producing Has potential implementation in a number of circumstances, Including photodamage of the skin.
Research Suggests That aussi nonapeptide-1 May play a role in the central nervous system Where It May act on Both dopaminergic receptors and opioid receptors to modify signaling bread as well as behavior. Studies in mice supporting the idea That nonapeptide-1 May-have central action That affect behavior and pain.
What Is Nonapeptide-1?
Nonapeptide-1 Was first isolated from the yeast Streptomyces clavifer, goal is Now Produced synthetically through recombinant genetic technology. It was first Developed for ict antimicrobial activities, goal HAS-been since found to be a strong inhibitor of melanin formation laboratory studies of yeast and melanoma (skin cancer) cells. Nonapeptide-1 Consists of the amino acids arginine-lysine-methionine-proline-phenylalanine-valine-tryptophan.
What Does Nonapeptide-1 Do?
In terms cosmeceutical, nonapeptide-1 promoter is a radiance and whitening agentv. In technical terms it is a melanin synthesis inhibitor that works by interfering with the actions of tyrosinase. Tyrosinase is the primary enzyme responsible for the synthesis of melanin in Specialized cells called Expired melanocytes. Any interference with tyrosinase prevent prevention melanocytes from Producing pigmentv . By inhibiting tyrosinase nonapeptide-1 can help to Reduce Production pigment in the skin in animal studies and THUS lighten darker areas-have beens That damaged by the sun and some diseases.
There is some evidence That nonapeptide-1 acts by interfering with melanocyte stimulating hormone (MSH). MSH Increases During Pregnancy, as a result of some medical condition (eg diabetes, Addison’s disease), and as a result of excessive sun exposure. MSH is a derivative of adrenocorticotropic hormone. Synthetic analogues of MSH, Such As Melanotan II, mimic the effects of the natural molecule and can lead to skin darkening. Interestingly, not everyone Responds to MSH. Red-heads, for instance, do not tan well Because They Have In Their variations MSH receptors That result in poor response to MSH in the blood.
Nonapeptide-1 Research on Skin Lightening
Research in fungi That indicates nonapeptide-1, at a concentration of 200 ug / ml, is fully able of inhibiting the synthesis of melanin2. Fungi are used in this research Particular Because They étroitement more approximate terms in human cells, require purpose Fewer resources than animal models. Research in animal models indicates That nonapeptide-1 May Effectively Reduce pigmentation, after-just one application for up to 28 days at a Timev . At 100 micromolar concentration, nonapeptide-1 can inhibit 25-35% of tyrosinase activity in animal models and can Reduce the melanin by melanocytes glad of 27-43%.