Pal-GHK (also called palmitoyl tripeptide-1 and palmitoyl oligopeptide) is a synthetic peptide known for its effects on collagen, skin health and skin pigments.
It is currently under investigation for its ability to stimulate collagen synthesis as well as its ability to reactivate the growth of blood vessels, for a more beautiful and glowing skin.
It acts on the healing of wounds and overpasses all anti-aging skin care.
In addition, PAL-GHK has other regenerative and protective actions, including antioxidant, anti-inflammatory and healing properties.
Recent studies have revealed its ability to up and down regulate a large number of human genes, including those that are essential for the development and maintenance of neurons.
Peptides (copper peptides) are small peptide fragments that naturally have a high affinity for copper ions.
In human plasma, the level of GHK-Cu is around 200 ng / ml in a 20-year-old individual.
At the age of 60, the GHK-Cu level drops to 80 ng / ml.
Scientific studies conducted in various research laboratories have established that in humans, Tripeptide GHK-Cu can promote wound healing, immune cell attraction, and also has potent anti-oxidant and anti-inflammatory effects.
In addition, it promotes the synthesis of collagen and glycosaminoglycans in skin fibroblasts as well as promoting the growth of blood vessels (angiogenesis).
Sequence (three letter code): Palmitoyl-Gly-His-Lys
Molecular formula: C30H54N6O5
Molecular weight: 578.8 g / mol
This fragment, composed of the amino acids glycine, histidine and lysine, is sometimes called GHK. In animal models, GHK has been shown to stimulate growth and reproduction of fibroblasts, which is of particular interest to researchers interested in wound healing, skin repair and tissue regeneration.
Pal-GHK is actively researched for its ability to improve the strength, softness and resilience of skin in animal models. Although GHK is responsible for the actual effects, it is the palmitoyl component that makes it so powerful. In fact, the attachment of palmitoyl to GHK is also sought for its ability to stimulate cutaneous and cellular penetration in animal models, a property that could make the fatty acid useful in other topical creams and ointments in cosmetic applications. and medical.
What does Pal-GHK do?
The GHK component of Pal-GHK deceives the fibroblasts into thinking that elastin, a common cutaneous protein, has been damaged. This induces the growth and multiplication of fibroblasts so that they can regenerate what they think is elastin lost in the skin. In aging animals, fibroblasts tend to lose their activity and become dormant. Studies on animal models indicate that GHK can re-energize fibroblasts and thus help overcome some of the common effects that aging on the skin.
The component and action of Peptide Pal-GHK:
By attaching this fatty acid to a peptide sequence, it is possible to achieve greater penetration of skin and cells in animal models. In other words, Pal’s job is to help GHK get where it can be most useful – the inside of cells deep within the skin.
Pal-GHK Research on reducing wrinkles and strengthening the skin
Pal-GHK has been shown, in animal models, to protect the skin against many effects of aging. In particular, Pal-GHK has been shown to stimulate the production of collagen and elastin. It seems to be particularly useful for restoring moisture and fullness of lips in animal models. When combined with other short peptides, Pal-GHK can work synergistically to reduce the appearance of fine lines and wrinkles. It has even been shown to help reduce redness and discoloration of the skin secondary to photodamage in animal studies.